Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 15/20 | 0.49 |
| ▸ | LCK | P06239 | 8/20 | 0.49 |
| ▸ | BLK | P51451 | 3/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | TEC | P42680 | 1/20 | 0.40 |
| ▸ | TXK | P42681 | 1/20 | 0.40 |
| ▸ | BMX | P51813 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825040 | 0.90 | BTK (0.49) | BTKLCKBLKCSF1RDAPK1 | |
| SCHEMBL3825451 | 0.89 | BTK (0.51) | BTKLCKBLKCSF1RDAPK1 | |
| SCHEMBL3825126 | 0.88 | BTK (0.49) | BTKLCKBLKCSF1RDAPK1 | |
| SCHEMBL3830492 | 0.86 | BTK (0.46) | BTKLCKBLKCSF1RDAPK1 | |
| SCHEMBL3824944 | 0.86 | BTK (0.46) | BTKLCKBLKCSF1RDAPK1 | |
| SCHEMBL3829780 | 0.86 | BTK (0.47) | BTKLCKBLKCSF1RDAPK1 | |
| SCHEMBL3824777 | 0.86 | MAPT (0.48) | BTKLCKCSF1RMAPTGAA | |
| SCHEMBL3824862 | 0.85 | BTK (0.53) | BTKLCKBLKBMX | |
| SCHEMBL3829466 | 0.85 | CSF1R (0.61) | LCKCSF1RDAPK1JAK3 | |
| SCHEMBL3830881 | 0.85 | BTK (0.49) | BTKLCKCSF1RDAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651648-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-02 | — | — | EP | claimed |
| JP-2007500725-A | — | — | 2007-01-18 | — | — | JP | claimed |
| EP-1651648-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-03 | — | — | EP | claimed |
| WO-2005011597-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-02-10 | — | — | WO | claimed |