Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 10/20 | 0.48 |
| ▸ | BTK | Q06187 | 7/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.45 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 4/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | WEE1 | P30291 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | BLK | P51451 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3827830 | 0.89 | LCK (0.54) | LCKBTKALKSRCJAK2 | |
| SCHEMBL3827191 | 0.85 | BTK (0.52) | LCKBTKCSF1RDAPK1BLK | |
| SCHEMBL3825382 | 0.85 | LCK (0.51) | LCKBTKKDRTEKMAPK14 | |
| SCHEMBL3825451 | 0.82 | BTK (0.51) | LCKBTKCSF1RDAPK1SRC | |
| SCHEMBL3832182 | 0.82 | MAPT (0.50) | LCKBTKCSF1RSRCABL1 | |
| SCHEMBL3827768 | 0.81 | LCK (0.44) | LCKBTKCSF1RDAPK1ALK | |
| SCHEMBL3130227 | 0.81 | LCK (0.60) | LCKSRCJAK2ABL1BCR | |
| SCHEMBL3828976 | 0.81 | LCK (0.43) | LCKBTKCSF1RDAPK1ALK | |
| SCHEMBL3825040 | 0.79 | BTK (0.49) | LCKBTKCSF1RDAPK1ABL1 | |
| SCHEMBL3830993 | 0.79 | BTK (0.49) | LCKBTKCSF1RDAPK1BLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651648-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-02 | — | — | EP | disclosed |
| EP-1651648-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005011597-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-02-10 | — | — | WO | disclosed |