Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CDC25B | P30305 | 3/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CDC25A | P30304 | 1/20 | 0.43 |
| ▸ | CDC25C | P30307 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13990442 | 0.82 | DHODH (0.48) | CDC25BMAPTALDH1A1ALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL10694179 | 0.78 | ALDH1A1 (0.57) | TSHRCDC25BCCR6MAPTALDH1A1 | |
| SCHEMBL8874138 | 0.76 | CYSLTR1 (0.59) | TSHRMAPTALDH1A1ALOX15CYP1A2 | |
| SCHEMBL8878647 | 0.76 | ALDH1A1 (0.69) | TSHRMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8875513 | 0.75 | CYP1A2 (0.49) | TSHRCDC25BCCR6MAPTALDH1A1 | |
| SCHEMBL21343984 | 0.74 | KDM4E (0.49) | TSHRCDC25BMAPTALDH1A1HSD17B10 | |
| SCHEMBL8875460 | 0.74 | ALDH1A1 (0.67) | TSHRMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL396552 | 0.74 | TSHR (0.69) | TSHRMAPTALDH1A1ALOX15CYP1A2 | |
| SCHEMBL11329873 | 0.73 | TSHR (0.54) | TSHRCDC25BMAPTALDH1A1CYP1A2 | |
| SCHEMBL23689805 | 0.73 | TSHR (0.62) | TSHRCDC25BMAPTALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1755585-A4 | TRANSTHYRETIN STABILIZATION | SCRIPPS RESEARCH INST (US) | 2009-04-01 | — | — | EP | disclosed |
| US-20080319175-A1 | Transthyretin Stabilization | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-25 | — | — | US | disclosed |
| EP-1755585-A1 | TRANSTHYRETIN STABILIZATION | The Scripps Research Institute (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005112913-A1 | TRANSTHYRETIN STABILIZATION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-12-01 | — | — | WO | disclosed |
| US-20050261365-A1 | Transthyretin stabilization | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261365-A1 | Transthyretin stabilization | TTR, TTPA, ALB | TSHR 1379/4885CDC25B 3167/4885PGR 4307/4885 |
| US-20080319175-A1 | Transthyretin Stabilization | TTR, TTPA, ALB | TSHR 1379/4885CDC25B 3167/4885PGR 4307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.