Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 12/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3816399 | 0.88 | CHEK1 (0.41) | CHEK1KCNH2RPS6KB1PDPK1CHRNB2 | |
| SCHEMBL3837254 | 0.86 | USP30 (0.39) | CHEK1KCNH2CHRNB2CHRNA4USP30 | |
| SCHEMBL3818264 | 0.79 | USP30 (0.41) | CHEK1KCNH2MAPK1CHRNB2CHRNA4 | |
| SCHEMBL3816591 | 0.77 | LMNA (0.40) | CHEK1JAK1JAK3USP30KDM4E | |
| SCHEMBL3851392 | 0.74 | SMN1; SMN2 (0.39) | JAK1JAK3KDM4ESMN1; SMN2 | |
| SCHEMBL4472754 | 0.72 | KDM4E (0.41) | USP30KDM4ESMN1; SMN2 | |
| SCHEMBL4474610 | 0.72 | USP30 (0.43) | CHEK1USP30SMN1; SMN2 | |
| SCHEMBL4467806 | 0.70 | JAK3 (0.41) | CHEK1JAK1JAK3USP30SMN1; SMN2 | |
| SCHEMBL4466084 | 0.70 | USP30 (0.41) | JAK1JAK3USP30SMN1; SMN2 | |
| SCHEMBL3818041 | 0.70 | KDM4E (0.37) | USP30KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742627-A4 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON INC (US) | 2009-08-26 | — | — | EP | disclosed |
| EP-1742627-A2 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2006078287-A2 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. (US) | 2006-07-27 | — | — | WO | disclosed |