Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | CSGALNACT1 | Q8TDX6 | 7/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3853232 | 0.86 | MELK (0.39) | SMN1; SMN2KDM4ELMNAMAPTTP53 | |
| SCHEMBL3824983 | 0.84 | MAPT (0.41) | SMN1; SMN2KDM4ELMNAMAPTTP53 | |
| SCHEMBL4484744 | 0.76 | NPC1 (0.43) | SMN1; SMN2LMNAMAPTRAB9AKMT2A | |
| SCHEMBL3824968 | 0.76 | MELK (0.46) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL13711814 | 0.75 | MELK (0.40) | SMN1; SMN2KDM4ELMNAMAPTTP53 | |
| SCHEMBL4468601 | 0.74 | MELK (0.48) | KDM4EMAPTKMT2APOLBMEN1 | |
| SCHEMBL3830469 | 0.74 | CHEK1 (0.39) | SMN1; SMN2KDM4EJAK1JAK3 | |
| SCHEMBL4464972 | 0.72 | MELK (0.42) | SMN1; SMN2KDM4ELMNAMAPTTP53 | |
| SCHEMBL4476871 | 0.68 | RAB9A (0.46) | SMN1; SMN2KDM4ELMNAMAPTRET | |
| SCHEMBL3989788 | 0.68 | MEN1 (0.53) | SMN1; SMN2KDM4EMAPTCSGALNACT1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742627-A4 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON INC (US) | 2009-08-26 | — | — | EP | disclosed |
| EP-1742627-A2 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2006078287-A2 | PDE4B INHIBITORS AND USES THEREFOR | PLEXXIKON, INC. (US) | 2006-07-27 | — | — | WO | disclosed |