Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.44 |
| ▸ | EGFR | P00533 | 5/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407663 | 0.91 | MET (0.46) | METKDR | |
| SCHEMBL20525860 | 0.85 | MET (0.46) | METKDR | |
| SCHEMBL3836016 | 0.83 | MET (0.43) | METEGFRKDRTRPA1 | |
| SCHEMBL3830873 | 0.82 | EGFR (0.49) | METEGFRKDR | |
| SCHEMBL2328224 | 0.81 | MET (0.43) | METKDRIRAK4 | |
| SCHEMBL2330038 | 0.80 | MET (0.45) | METKDR | |
| SCHEMBL15520452 | 0.80 | KDR (0.45) | METEGFRKDRTRPA1IRAK4 | |
| SCHEMBL371983 | 0.80 | MET (0.54) | METEGFRKDR | |
| SCHEMBL2200943 | 0.78 | MET (0.53) | METKDR | |
| SCHEMBL3858219 | 0.77 | MET (0.55) | METKDRIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-A1 | METHODS OF USING MEK INHIBITORS | Exelixis, Inc. (US) | 2009-09-23 | — | — | EP | claimed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | claimed |