SCHEMBL3830935

SCHEMBL3830935

CC(c1nc2cc(-c3ncccn3)ccc2[nH]1)c1nc2cc(-c3ncccn3)ccc2[nH]1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.46
LMNA P02545 1/20 0.46
HSD17B10 Q99714 1/20 0.46
AAK1 Q2M2I8 8/20 0.37
PIK3CD O00329 1/20 0.37
PIP5K1C O60331 1/20 0.37
PI4KA P42356 1/20 0.37
PIK3CG P48736 1/20 0.37
PI4KB Q9UBF8 1/20 0.37
HDAC1 Q13547 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
HDAC5 Q9UQL6 1/20 0.36
TAAR1 Q96RJ0 1/20 0.36
IDO1 P14902 1/20 0.36
ALDH1A1 P00352 1/20 0.36
POLB P06746 1/20 0.36
MLKL Q8NB16 1/20 0.35
DYRK1A Q13627 1/20 0.35
CLK4 Q9HAZ1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27631254 0.88 AAK1 (0.49) KDM4ELMNAHSD17B10AAK1ALDH1A1
SCHEMBL3833275 0.84 KDM4E (0.40) KDM4ELMNAHSD17B10AAK1PIK3CD
SCHEMBL3835605 0.82 KDM4E (0.38) KDM4ELMNAHSD17B10AAK1PIK3CD
SCHEMBL3835038 0.82 KDM4E (0.38) KDM4ELMNAHSD17B10AAK1PIK3CD
SCHEMBL3830605 0.82 KDM4E (0.39) KDM4ELMNAHSD17B10AAK1TAAR1
SCHEMBL4392245 0.80 ALDH1A1 (0.40) KDM4ELMNAHSD17B10AAK1IDO1
SCHEMBL5306795 0.80 RAB9A (0.48) KDM4ELMNAHSD17B10PIK3CDPIP5K1C
SCHEMBL3830827 0.79 KDM4E (0.36) KDM4ELMNAHSD17B10AAK1PIK3CD
SCHEMBL549128 0.79 AAK1 (0.40) KDM4ELMNAHSD17B10AAK1POLB
SCHEMBL3837411 0.78 NISCH (0.44) KDM4ELMNAHSD17B10AAK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1651211-A4 COMBINATION OF DRUGS FOR THE TREATMENT OF NEOPLASMS COMBINATORX INC (US) 2006-11-22 EP claimed
EP-1651211-A2 COMBINATION OF DRUGS FOR THE TREATMENT OF NEOPLASMS Combinatorx, Incorporated (US) 2006-05-03 EP claimed
EP-1545544-A2 COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS Combinatorx, Incorporated (US) 2005-06-29 EP claimed
WO-2005020913-A2 FORMULATIONS, CONJUGATES, AND COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS COMBINATORX, INCORPORATED (US) 2005-03-10 WO claimed
WO-2005011572-A2 COMBINATION OF DRUGS FOR THE TREATMENT OF NEOPLASMS COMBINATORX, INCORPORATED (US) 2005-02-10 WO claimed
WO-2004006842-A2 COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS COMBINATORX, INCORPORATED (US) 2004-01-22 WO claimed
WO-2004006849-A2 COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS COMBINATORX, INCORPORATED (US) 2004-01-22 WO claimed
EP-2121700-A1 SUBSTITUTED TETRAHYDROQUINOLINES Merck Patent GmbH (DE) 2009-11-25 EP disclosed
EP-2121706-A1 TETRAHYDROQUINOLINE DERIVATIVES AND USE OF SAME FOR TREATING CANCER Merck Patent GmbH (DE) 2009-11-25 EP disclosed
EP-2121684-A1 SUBSTITUTED TETRAHYDROPYRROLOQUINOLINES Merck Patent GmbH (DE) 2009-11-25 EP disclosed
EP-2104664-A1 TETRAHYDROBENZOISOXAZOLE - AND TETRAHYDROINDAZOLE DERIVATIVES AS MODULATORS OF THE MITOTIC MOTOR PROTEIN Merck Patent GmbH (DE) 2009-09-30 EP disclosed
WO-2008113456-A1 TETRAHYDROQUINOLINE DERIVATIVES AND USE OF SAME FOR TREATING CANCER MERCK PATENT GMBH (DE) 2008-09-25 WO disclosed
WO-2008113451-A1 SUBSTITUTED TETRAHYDROQUINOLINES MERCK PATENT GMBH (DE) 2008-09-25 WO disclosed
WO-2006002726-A1 TETRAHYDROQUINOLINES MERCK PATENT GMBH (DE) 2006-01-12 WO disclosed
WO-2005108355-A2 DIHYDROBENZOTHIOPHENES MERCK PATENT GMBH (DE) 2005-11-17 WO disclosed
EP-1545544-A2 COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS Combinatorx, Incorporated (US) 2005-06-29 EP disclosed
WO-2005020913-A2 FORMULATIONS, CONJUGATES, AND COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS COMBINATORX, INCORPORATED (US) 2005-03-10 WO disclosed
WO-2004006842-A2 COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS COMBINATORX, INCORPORATED (US) 2004-01-22 WO disclosed
WO-2004006849-A2 COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS COMBINATORX, INCORPORATED (US) 2004-01-22 WO disclosed
WO-2004002430-A2 COMBINATIONS FOR THE TREATMENT OF FUNGAL INFECTIONS COMBINATORX INCORPORATED (US) 2004-01-08 WO disclosed