Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.59 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 5/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831529 | 0.90 | GRM5 (0.60) | GRM5CES2HTR6HTR1AHTR2A | |
| SCHEMBL3834912 | 0.90 | GRM5 (0.67) | GRM5CES2HTR6HTR1AHTR2A | |
| SCHEMBL3835283 | 0.89 | GRM5 (0.59) | GRM5CES2HTR6HTR1AHTR2A | |
| SCHEMBL3836709 | 0.89 | GRM5 (0.60) | GRM5CES2HTR6HTR1AHTR2A | |
| SCHEMBL3835262 | 0.88 | GRM5 (0.72) | GRM5CES2HTR6HTR2A | |
| SCHEMBL3837297 | 0.87 | CES2 (0.64) | GRM5CES2POLBADRB2 | |
| SCHEMBL3832742 | 0.86 | GRM5 (0.62) | GRM5CES2SMN1; SMN2ADRB2 | |
| SCHEMBL3834589 | 0.85 | GRM5 (0.58) | GRM5CES2THRBPOLBADRB2 | |
| SCHEMBL3836529 | 0.85 | GRM5 (0.55) | GRM5CES2HTR6HTR1AHTR2A | |
| SCHEMBL13677006 | 0.84 | GRM5 (0.83) | GRM5CES2HTR6HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962849-B1 | QUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF MGLUR5 RECEPTOR-MEDIATED DISORDERS | RICHTER GEDEON NYRT (HU) | 2009-09-30 | — | — | EP | claimed |