Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.59 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13677015 | 0.93 | GRM5 (0.60) | GRM5CES2HTR6HTR1AHTR2A | |
| SCHEMBL3832691 | 0.91 | GRM5 (0.61) | GRM5CES2HTR6HTR1AHTR2A | |
| SCHEMBL13677020 | 0.90 | GRM5 (0.66) | GRM5CES2HTR6HTR1AHTR2A | |
| SCHEMBL13677021 | 0.90 | GRM5 (0.70) | GRM5CES2HTR6HTR2A | |
| SCHEMBL3836518 | 0.90 | GRM5 (0.57) | GRM5CES2HTR6HTR1AHTR2A | |
| SCHEMBL3836170 | 0.90 | GRM5 (0.69) | GRM5CES2HTR6HTR1AHTR2A | |
| SCHEMBL3830976 | 0.89 | GRM5 (0.59) | GRM5CES2HTR6HTR1AHTR2A | |
| SCHEMBL13677019 | 0.89 | GRM5 (0.71) | GRM5CES2HTR6HTR1AHTR2A | |
| SCHEMBL13677017 | 0.87 | GRM5 (0.65) | GRM5CES2 | |
| SCHEMBL3834028 | 0.86 | GRM5 (0.58) | GRM5CES2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962849-B1 | QUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF MGLUR5 RECEPTOR-MEDIATED DISORDERS | RICHTER GEDEON NYRT (HU) | 2009-09-30 | — | — | EP | claimed |