Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 5/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 7/20 | 0.47 |
| ▸ | DRD3 | P35462 | 7/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | CCNK | O75909 | 1/20 | 0.43 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382583 | 1.00 | CASR (0.54) | CASRUSP2HDAC1HDAC8HDAC6 | |
| SCHEMBL7053339 | 0.93 | CASR (0.54) | CASRUSP2HDAC1HDAC8HDAC6 | |
| SCHEMBL7463214 | 0.93 | CASR (0.54) | CASRUSP2HDAC1HDAC8HDAC6 | |
| SCHEMBL383016 | 0.92 | DRD2 (0.55) | CASRUSP2DRD2DRD3HPGDS | |
| SCHEMBL7467132 | 0.91 | CASR (0.51) | CASRUSP2HDAC1HDAC8HDAC6 | |
| SCHEMBL2408945 | 0.88 | CASR (0.54) | CASRUSP2HDAC1HDAC8HDAC6 | |
| SCHEMBL23500656 | 0.85 | HDAC1 (0.48) | CASRHDAC1HDAC8HDAC6DRD2 | |
| SCHEMBL382149 | 0.83 | OPRK1 (0.51) | HDAC1HDAC8HDAC6DRD2DRD3 | |
| SCHEMBL383015 | 0.83 | OPRK1 (0.51) | HDAC1HDAC8HDAC6DRD2DRD3 | |
| SCHEMBL2412579 | 0.82 | HDAC1 (0.57) | CASRUSP2HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |