Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | P4HTM | Q9NXG6 | 6/20 | 0.46 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.46 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL3832171 | 1.00 | MAP4K4 (0.50) | MAP4K4P4HTMP4HA1MIFKDM4E | |
| Bicarbonate SCHEMBL3832170 | 0.97 | MAP4K4 (0.50) | MAP4K4P4HTMP4HA1MIFKDM4E | |
| SCHEMBL1951045 | 0.93 | MAP4K4 (0.55) | MAP4K4P4HTMP4HA1MIFKDM4E | |
| SCHEMBL13731115 | 0.82 | P4HTM (0.64) | MAP4K4P4HTMP4HA1MIFKDM4E | |
| SCHEMBL254682 | 0.79 | MAP4K4 (0.55) | MAP4K4P4HTMP4HA1MIFKDM4E | |
| SCHEMBL71034 | 0.74 | HIF1A (0.55) | MAP4K4P4HTMP4HA1MIFKDM4E | |
| SCHEMBL29929320 | 0.74 | HIF1A (0.55) | MAP4K4P4HTMP4HA1MIFKDM4E | |
| SCHEMBL1867850 | 0.73 | MAP4K4 (0.57) | MAP4K4LMNAMAPT | |
| SCHEMBL11044314 | 0.73 | P4HTM (0.53) | MAP4K4P4HTMP4HA1MIFKDM4E | |
| SCHEMBL28654391 | 0.73 | P4HTM (0.70) | MAP4K4P4HTMP4HA1MIFKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099447-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | Incyte Corporation (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008064157-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |