Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2906698 | 0.90 | MET (0.53) | METKDR | |
| SCHEMBL3830889 | 0.88 | MET (0.55) | METIRAK4FLT3 | |
| SCHEMBL3830897 | 0.88 | MET (0.55) | METIRAK4FLT3 | |
| SCHEMBL3832583 | 0.88 | MET (0.57) | METIRAK4FLT3KDR | |
| SCHEMBL2902292 | 0.87 | MET (0.54) | METIRAK4FLT3KDR | |
| SCHEMBL5570609 | 0.87 | MET (0.55) | METIRAK4FLT3KDR | |
| SCHEMBL4472599 | 0.87 | MET (0.56) | METIRAK4FLT3 | |
| SCHEMBL3857815 | 0.87 | MET (0.56) | METIRAK4FLT3 | |
| SCHEMBL3858219 | 0.86 | MET (0.55) | METIRAK4FLT3KDR | |
| SCHEMBL3848541 | 0.86 | MET (0.55) | METIRAK4FLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-A1 | METHODS OF USING MEK INHIBITORS | Exelixis, Inc. (US) | 2009-09-23 | — | — | EP | claimed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | claimed |