Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.56 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3832744 | 0.95 | MET (0.51) | METIRAK4FLT3 | |
| SCHEMBL3833678 | 0.94 | MET (0.51) | METIRAK4FLT3 | |
| SCHEMBL3829169 | 0.94 | MET (0.52) | METIRAK4FLT3 | |
| SCHEMBL3834684 | 0.93 | MET (0.50) | METIRAK4FLT3 | |
| SCHEMBL3854817 | 0.93 | MET (0.53) | METIRAK4FLT3 | |
| SCHEMBL3830889 | 0.92 | MET (0.55) | METIRAK4FLT3 | |
| SCHEMBL3830897 | 0.92 | MET (0.55) | METIRAK4FLT3 | |
| SCHEMBL2902292 | 0.91 | MET (0.54) | METIRAK4FLT3 | |
| SCHEMBL3832327 | 0.87 | MET (0.54) | METIRAK4FLT3 | |
| SCHEMBL3976731 | 0.86 | MET (0.56) | METIRAK4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| EP-2392564-B1 | c-Met modulators and methods of use | EXELIXIS INC (US) | 2013-10-23 | — | — | EP | disclosed |