Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | FAP | Q12884 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3833195 | 1.00 | KDM4E (0.46) | KDM4EALDH1A1MAPTCCR3EPHX2 | |
| SCHEMBL13853650 | 0.84 | GRM5 (0.47) | KDM4EALDH1A1MAPTCCR3EPHX2 | |
| SCHEMBL31348898 | 0.83 | ITGB3 (0.43) | KDM4EALDH1A1EPHX2KMT2AITGB3 | |
| SCHEMBL5901263 | 0.83 | MTNR1A (0.42) | — | |
| SCHEMBL21625089 | 0.82 | ITGB3 (0.45) | KDM4EALDH1A1MAPTEPHX2KMT2A | |
| SCHEMBL17207607 | 0.81 | CCR3 (0.44) | KDM4EALDH1A1MAPTCCR3FAP | |
| SCHEMBL14155724 | 0.81 | CCR3 (0.44) | KDM4EALDH1A1MAPTCCR3FAP | |
| SCHEMBL14559366 | 0.81 | CCR3 (0.44) | KDM4EALDH1A1MAPTCCR3FAP | |
| SCHEMBL2706533 | 0.81 | KDM4E (0.46) | KDM4EALDH1A1MAPTEPHX2KMT2A | |
| SCHEMBL17207589 | 0.80 | ACKR3 (0.57) | KDM4EALDH1A1MAPTKMT2AACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102171-A1 | NEW PYRIDAZINE DERIVATIVES WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS | Boehringer Ingelheim International GmbH (DE) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008071646-A1 | NEW PYRIDAZINE DERIVATIVES WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-06-19 | — | — | WO | disclosed |