Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | USP1 | O94782 | 2/20 | 0.46 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28619486 | 0.85 | HSD11B1 (0.56) | SCN9AHSD11B1ARSTK10SLK | |
| SCHEMBL9258898 | 0.81 | TRPA1 (0.45) | PDK2TRPA1GAAKMT2A | |
| SCHEMBL30146607 | 0.81 | SCN9A (0.59) | SCN9AHSD11B1ARTRPA1BACE1 | |
| SCHEMBL9890661 | 0.80 | PDK2 (0.45) | SCN9APDK2GAAKMT2A | |
| SCHEMBL1408512 | 0.80 | GAA (0.59) | SCN9APDK2KDM4EALDH1A1LMNA | |
| SCHEMBL9862849 | 0.80 | NPC1 (0.50) | PDK2ALDH1A1GAAKMT2A | |
| SCHEMBL5112656 | 0.79 | SCN9A (0.54) | SCN9AARSTK10SLKPDK2 | |
| SCHEMBL2395495 | 0.79 | SCN9A (0.47) | SCN9APDK2GAAHPGDKMT2A | |
| SCHEMBL5540255 | 0.78 | SCN9A (0.53) | SCN9AHSD11B1ARTRPA1BACE1 | |
| SCHEMBL5540262 | 0.78 | SCN9A (0.53) | SCN9AHSD11B1ARPDK2TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946508-B1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2009-09-23 | — | — | EP | disclosed |