Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 11/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3833501 | 1.00 | CCR5 (0.36) | CCR5KCNH2MCHR1PARP1PARP2 | |
| SCHEMBL3762693 | 0.77 | MCHR1 (0.40) | CCR5KCNH2MCHR1SIGMAR1 | |
| SCHEMBL3758106 | 0.77 | MCHR1 (0.40) | CCR5KCNH2MCHR1SIGMAR1 | |
| SCHEMBL3762699 | 0.76 | MCHR1 (0.42) | CCR5KCNH2MCHR1 | |
| SCHEMBL3758110 | 0.76 | MCHR1 (0.42) | CCR5KCNH2MCHR1 | |
| SCHEMBL3832667 | 0.75 | CCR5 (0.47) | CCR5KCNH2MCHR1 | |
| SCHEMBL3832661 | 0.75 | CCR5 (0.47) | CCR5KCNH2MCHR1 | |
| SCHEMBL3833497 | 0.74 | CCR5 (0.49) | CCR5KCNH2 | |
| SCHEMBL3757433 | 0.70 | CCR5 (0.45) | CCR5KCNH2MCHR1 | |
| SCHEMBL3757430 | 0.70 | CCR5 (0.45) | CCR5KCNH2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942890-A4 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORP (US) | 2009-08-26 | — | — | EP | disclosed |
| EP-1942890-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2008-07-16 | — | — | EP | disclosed |
| WO-2006138350-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2006-12-28 | — | — | WO | disclosed |