Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.42 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | PRMT3 | O60678 | 2/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837972 | 0.94 | ROCK2 (0.43) | ROCK2ROCK1CCR2IMPDH2PRMT3 | |
| SCHEMBL3833348 | 0.85 | ROCK2 (0.43) | ROCK2ROCK1CCR2PRMT3KMT2A | |
| SCHEMBL3313804 | 0.77 | ROCK2 (0.67) | ROCK2ROCK1CCR2 | |
| SCHEMBL3313164 | 0.77 | ROCK2 (0.67) | ROCK2ROCK1CCR2 | |
| SCHEMBL3313248 | 0.76 | PRMT3 (0.40) | ROCK2ROCK1IMPDH2PRMT3 | |
| SCHEMBL3313256 | 0.76 | PRMT3 (0.40) | ROCK2ROCK1IMPDH2PRMT3 | |
| SCHEMBL3313669 | 0.74 | ROCK2 (0.55) | ROCK2ROCK1CCR2PRMT3 | |
| SCHEMBL3313905 | 0.74 | ROCK2 (0.55) | ROCK2ROCK1CCR2PRMT3 | |
| SCHEMBL3312172 | 0.74 | ROCK2 (0.53) | ROCK2ROCK1CCR2 | |
| SCHEMBL3318830 | 0.74 | PRMT3 (0.41) | ROCK2ROCK1CCR2PRMT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114920-A1 | SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008077552-A1 | SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | disclosed |