Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.38 |
| ▸ | XDH | P47989 | 3/20 | 0.38 |
| ▸ | CES2 | O00748 | 5/20 | 0.36 |
| ▸ | CES1 | P23141 | 5/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | GYS1 | P13807 | 1/20 | 0.31 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
| ▸ | P4HB | P07237 | 1/20 | 0.31 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4823128 | 0.86 | SLC22A12 (0.46) | SLC22A12XDHKDM4EHSD17B10KEAP1 | |
| SCHEMBL16844542 | 0.81 | MAPT (0.40) | SLC22A12XDHKDM4EPOLBMAPT | |
| SCHEMBL30367823 | 0.81 | PARP1 (0.43) | SLC22A12XDHKDM4EPOLBMAPT | |
| Hydrochloric Acid SCHEMBL28438885 | 0.79 | PARP1 (0.44) | SLC22A12XDHKDM4EPOLBMAPT | |
| SCHEMBL3837130 | 0.78 | KCNA3 (0.43) | SLC22A12KDM4EPOLBMAPTHSD17B10 | |
| SCHEMBL2263622 | 0.77 | MAPT (0.41) | PTPN1KDM4EPOLBMAPTHSD17B10 | |
| SCHEMBL3832066 | 0.75 | PTPN1 (0.41) | PTPN1POLBHSD17B10KEAP1RORC | |
| SCHEMBL4992573 | 0.71 | MEN1 (0.47) | PTPN1KDM4EMAPTHSD17B10 | |
| SCHEMBL7481290 | 0.71 | CA9 (0.44) | SLC22A12XDHPTPN1KDM4EPOLB | |
| Oxalic Acid SCHEMBL5987436 | 0.70 | MEN1 (0.36) | SLC22A12XDHKDM4EMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110294792-A1 | PURINE DERIVATIVES AS KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-12-01 | — | — | US | disclosed |
| US-20090105229-A1 | PURINE DERIVATIVES AS KINASE INHIBITORS | ELI LILLY AND COMPANY | 2009-04-23 | — | — | US | disclosed |
| EP-1483265-B1 | PURINE DERIVATIVES AS KINASE INHIBITORS | LILLY CO ELI (US) | 2006-11-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294792-A1 | PURINE DERIVATIVES AS KINASE INHIBITORS | PNP, ADK, NME2 | SLC22A12 2344/4885XDH 346/4885CES2 3398/4885 |
| US-20090105229-A1 | PURINE DERIVATIVES AS KINASE INHIBITORS | PNP, ADK, NME2 | SLC22A12 2344/4885XDH 346/4885CES2 3398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.