Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.37 |
| ▸ | MME | P08473 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12574153 | 0.92 | HPGD (0.39) | MAPTHPGDFPR2ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL2022552 | 0.90 | HPGD (0.38) | MAPTHPGDFPR2ALDH1A1KMT2A | |
| SCHEMBL14968777 | 0.84 | EPHX1 (0.48) | MAPTHPGDFPR2ALDH1A1KMT2A | |
| SCHEMBL3835572 | 0.80 | MAPT (0.40) | MAPTHPGDFPR2ALDH1A1KMT2A | |
| SCHEMBL21916708 | 0.76 | KDM4E (0.39) | MAPTALDH1A1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL14161850 | 0.75 | CCR2 (0.49) | MAPTHPGDALDH1A1EPHX1MME | |
| SCHEMBL15463102 | 0.74 | HPGD (0.40) | MAPTHPGDALDH1A1KMT2AEPHX1 | |
| SCHEMBL7522834 | 0.74 | CYP3A4 (0.40) | MAPTALDH1A1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL28826594 | 0.73 | CCR2 (0.51) | MAPTHPGDALDH1A1KMT2AEPHX1 | |
| SCHEMBL7432178 | 0.72 | HDAC4 (0.40) | KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053523-B | Azetidines as MEK inhibitors for the treatment of proliferative diseases | 埃克塞利希斯股份有限公司 | 2022-03-25 | — | — | CN | disclosed |
| CN-111643496-A | Methods of using MEK inhibitors | 埃克塞利希斯股份有限公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-110668988-A | Azetidines as MEK inhibitors for the treatment of proliferative diseases | 埃克塞利希斯股份有限公司 | 2020-01-10 | — | — | CN | disclosed |
| EP-2101759-A1 | METHODS OF USING MEK INHIBITORS | Exelixis, Inc. (US) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |