Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K9 | P80192 | 1/20 | 0.48 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | WEE1 | P30291 | 1/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3835838 | 0.85 | TDP2 (0.42) | MAP3K9MAP3K11CLK1CLK2CLK3 | |
| SCHEMBL3043388 | 0.81 | KDR (0.54) | MAP3K9MAP3K11CLK1CLK2CLK3 | |
| SCHEMBL12469163 | 0.80 | KDR (0.40) | MAP3K9MAP3K11KDRTDP2MAOA | |
| SCHEMBL3039949 | 0.75 | MAP3K9 (0.50) | MAP3K9MAP3K11CLK1CLK2CLK3 | |
| SCHEMBL3049982 | 0.74 | KDR (0.54) | MAP3K9MAP3K11CLK1CLK2CLK3 | |
| SCHEMBL3840842 | 0.73 | KDR (0.71) | KDRNTRK2CLK4 | |
| SCHEMBL30331758 | 0.72 | PARP10 (0.69) | KDRPARP10PARP11TYRO3NTRK2 | |
| SCHEMBL18171019 | 0.71 | MAP3K9 (0.47) | MAP3K9MAP3K11CLK1CLK2CLK3 | |
| SCHEMBL28204088 | 0.71 | MAOA (0.61) | MAOAALDH1A1MAPTBRD4 | |
| SCHEMBL7771393 | 0.71 | MAOA (0.61) | MAOAALDH1A1MAPTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |