Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.76 |
| ▸ | MEN1 | O00255 | 5/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | POLB | P06746 | 3/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12167759 | 0.95 | MAPT (0.73) | MAPTKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL11316237 | 0.94 | MAPT (0.76) | MAPTKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL11318162 | 0.92 | MAPT (0.73) | MAPTKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL31503975 | 0.86 | LMNA (0.78) | MAPTKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL8977175 | 0.85 | ALDH1A1 (0.73) | MAPTKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL8977180 | 0.85 | ALDH1A1 (0.78) | MAPTKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL5418542 | 0.84 | MAPT (0.73) | MAPTKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL3498895 | 0.83 | LMNA (0.78) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL23323321 | 0.83 | MEN1 (0.68) | MAPTKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL11306038 | 0.83 | MAPT (0.57) | MAPTKMT2AMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718402-B1 | Penicillin V amidohydrolase gene from fusarium oxysporum | BRISTOL MYERS SQUIBB CO (US) | 2009-09-30 | — | — | EP | disclosed |
| EP-0718402-A2 | Penicillin V amidohydrolase gene from fusarium oxysporum | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-06-26 | — | — | EP | disclosed |
| US-5516679-A | GENETIC ENGINEERING | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-05-14 | — | — | US | disclosed |