Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.38 |
| ▸ | PPARG | P37231 | 7/20 | 0.38 |
| ▸ | PPARD | Q03181 | 7/20 | 0.38 |
| ▸ | PPARA | Q07869 | 7/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.38 |
| ▸ | TLR2 | O60603 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | FABP4 | P15090 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5606283 | 0.84 | GAA (0.41) | TSHRALDH1A1TDP1HSD17B10 | |
| SCHEMBL27621484 | 0.74 | TSHR (0.44) | ABCC4MAPTLMNATSHRNFKB1 | |
| SCHEMBL10778866 | 0.74 | GAA (0.39) | ABCC4MAPTLMNATSHRNFKB1 | |
| SCHEMBL21560981 | 0.73 | LMNA (0.44) | LMNATSHRNFKB1PMP22AKR1B1 | |
| SCHEMBL9808504 | 0.73 | ABCC4 (0.46) | ABCC4MAPTLMNATSHRNFKB1 | |
| Adipic Acid SCHEMBL7653370 | 0.72 | ABCC4 (0.48) | ABCC4MAPTLMNATSHRNFKB1 | |
| SCHEMBL19333419 | 0.72 | TSHR (0.46) | LMNATSHRNFKB1PMP22ALDH1A1 | |
| SCHEMBL22500690 | 0.71 | ABCC4 (0.47) | ABCC4MAPTLMNATSHRNFKB1 | |
| Sebacic Acid SCHEMBL27800153 | 0.71 | ABCC4 (0.52) | ABCC4MAPTLMNATSHRNFKB1 | |
| SCHEMBL27757682 | 0.71 | ABCC4 (0.52) | ABCC4MAPTLMNATSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448508-B1 | DOUBLE ESTERS | DRUG DISCOVERY LAB AS (NO) | 2009-09-23 | — | — | EP | claimed |
| EP-1448508-B1 | DOUBLE ESTERS | DRUG DISCOVERY LAB AS (NO) | 2009-09-23 | — | — | EP | disclosed |