Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28081734 | 0.81 | ITGB3 (0.53) | SMN1; SMN2KMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL16759937 | 0.81 | NOTUM (0.52) | SMN1; SMN2KMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL31240267 | 0.81 | NOTUM (0.55) | SMN1; SMN2KMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL2035385 | 0.81 | NOTUM (0.55) | SMN1; SMN2KMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL14398105 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL432319 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2KMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL15664724 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2KMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL630857 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2KMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL7978483 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2KMT2AMEN1ALDH1A1KEAP1 | |
| SCHEMBL7981185 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2KMT2AMEN1ALDH1A1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125870-A1 | INHIBITORS OF HEPATITIS C NS3 PROTEASE | Boehringer Ingelheim International GmbH (DE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008098368-A1 | INHIBITORS OF HEPATITIS C NS3 PROTEASE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-21 | — | — | WO | disclosed |