Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.45 |
| ▸ | HAT1 | O14929 | 2/20 | 0.44 |
| ▸ | EP300 | Q09472 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496758 | 0.86 | NPC1 (0.60) | NPC1RAB9AEPHB3ADORA2ANPSR1 | |
| Hydrochloric Acid SCHEMBL21834227 | 0.84 | NPC1 (0.59) | NPC1RAB9AEPHB3ADORA2ANPSR1 | |
| SCHEMBL11266749 | 0.81 | NPC1 (0.78) | NPC1RAB9AEPHB3ADORA2ANPSR1 | |
| SCHEMBL1027478 | 0.81 | NPC1 (0.52) | NPC1RAB9AEPHB3ADORA2ANPSR1 | |
| SCHEMBL3549382 | 0.81 | NPC1 (0.59) | NPC1RAB9AEPHB3ADORA2ANPSR1 | |
| SCHEMBL2017759 | 0.81 | NPC1 (0.59) | NPC1RAB9AEPHB3ADORA2ANPSR1 | |
| SCHEMBL14743372 | 0.81 | NPC1 (0.63) | NPC1RAB9AEPHB3ADORA2ANPSR1 | |
| SCHEMBL28564762 | 0.80 | NPC1 (0.51) | NPC1RAB9AEPHB3ADORA2ANPSR1 | |
| SCHEMBL28912172 | 0.80 | NPC1 (0.58) | NPC1RAB9AEPHB3ADORA2ANPSR1 | |
| Hydrochloric Acid SCHEMBL14746375 | 0.79 | NPC1 (0.61) | NPC1RAB9AEPHB3ADORA2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014091386-A2 | AN IMPROVED PROCESS FOR PREPARATION OF MINODRONIC ACID | ALEMBIC PHARMACEUTICALS LIMITED (IN) | 2014-06-19 | — | — | WO | disclosed |
| US-20110294792-A1 | PURINE DERIVATIVES AS KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-12-01 | — | — | US | disclosed |
| US-20090105229-A1 | PURINE DERIVATIVES AS KINASE INHIBITORS | ELI LILLY AND COMPANY | 2009-04-23 | — | — | US | disclosed |
| US-7405305-B2 | Pyrrole-2, 5dione derivatives and their used as GSK-3 inhibitors | ELI LILLY AND COMPANY (US) | 2008-07-29 | — | — | US | disclosed |
| EP-1483265-B1 | PURINE DERIVATIVES AS KINASE INHIBITORS | LILLY CO ELI (US) | 2006-11-22 | — | — | EP | disclosed |
| US-20050288321-A1 | Kinase inhibitors | ELI LILLY AND COMPANY | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294792-A1 | PURINE DERIVATIVES AS KINASE INHIBITORS | PNP, ADK, NME2 | NPC1 2000/4885RAB9A 3399/4885EPHB3 1036/4885 |
| US-20090105229-A1 | PURINE DERIVATIVES AS KINASE INHIBITORS | PNP, ADK, NME2 | NPC1 2000/4885RAB9A 3399/4885EPHB3 1036/4885 |
| US-20050288321-A1 | Kinase inhibitors | ABL1, MAP3K20, MAP3K19 | NPC1 2414/4885RAB9A 1957/4885EPHB3 1785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.