Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1162743 | 0.93 | CTSL (0.45) | CTSLCTSBCTSSHTTLMNA | |
| SCHEMBL4110578 | 0.93 | CTSS (0.55) | CTSLCTSBCTSSHTTLMNA | |
| SCHEMBL14894910 | 0.88 | NPC1 (0.47) | CTSLCTSBCTSSHTTLMNA | |
| SCHEMBL14894968 | 0.86 | CTSL (0.44) | CTSLCTSBCTSSHTTLMNA | |
| SCHEMBL381668 | 0.86 | CTSL (0.50) | CTSLCTSBCTSSHTTLMNA | |
| SCHEMBL6897899 | 0.85 | HTT (0.54) | CTSLCTSBCTSSHTTLMNA | |
| SCHEMBL19442303 | 0.85 | CTSL (0.49) | CTSLCTSBCTSSHTTLMNA | |
| SCHEMBL12070062 | 0.85 | CTSL (0.49) | CTSLCTSBCTSSHTTLMNA | |
| SCHEMBL16219332 | 0.85 | CTSL (0.52) | CTSLCTSBCTSSHTTLMNA | |
| SCHEMBL7950582 | 0.85 | CA12 (0.50) | CTSLCTSBCTSSHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149213-A2 | NOVEL DERIVATIVE HAVING INHIBITORY ACTIVITY AGAINST 11Β-HSD1, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT | 주식회사 이큐스앤자루 (KR) | 2011-12-01 | — | — | WO | disclosed |
| EP-1658267-B1 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2009-10-14 | — | — | EP | disclosed |
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |