Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8118746 | 0.82 | HDAC1 (0.46) | FFAR1HDAC1HDAC6HDAC5HDAC8 | |
| SCHEMBL3839020 | 0.82 | FFAR1 (0.40) | FFAR1TP53KDM4ETDP1MRGPRX4 | |
| SCHEMBL3836799 | 0.80 | TP53 (0.40) | FFAR1TP53HTTDAOL3MBTL1 | |
| SCHEMBL3839877 | 0.72 | FFAR1 (0.34) | FFAR1TP53HTTL3MBTL1KDM4E | |
| SCHEMBL224611 | 0.69 | TP53 (0.45) | FFAR1HDAC6TP53HTTL3MBTL1 | |
| SCHEMBL224876 | 0.69 | MEN1 (0.44) | FFAR1HDAC1HDAC6HDAC5HDAC8 | |
| SCHEMBL17253574 | 0.68 | RAB9A (0.52) | HTTKDM4ETDP1RAB9ASMN1; SMN2 | |
| SCHEMBL3839731 | 0.68 | FFAR1 (0.47) | FFAR1TP53KDM4ENPC1RAB9A | |
| SCHEMBL4342702 | 0.66 | SYK (0.67) | FFAR1TP53HTTKDM4ENPC1 | |
| SCHEMBL4569960 | 0.66 | SYK (0.59) | FFAR1HDAC1HDAC6HDAC5L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094668-A2 | 4-IMIDAZOLINES AS TAAR'S LIGANDS | F. Hoffmann-Roche AG (CH) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008074679-A2 | 4-IMIDAZOLINES AS TAAR'S LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-26 | — | — | WO | disclosed |