Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL224611 | 0.91 | TP53 (0.45) | TP53HTTMEN1KMT2ACYP1A2 | |
| SCHEMBL224876 | 0.91 | MEN1 (0.44) | MEN1KMT2ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL3839017 | 0.82 | MRGPRX4 (0.39) | TP53HTTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6358732 | 0.80 | ALDH1A1 (0.38) | MEN1KMT2AL3MBTL1NPC1RAB9A | |
| SCHEMBL222798 | 0.80 | MRGPRX4 (0.46) | TP53HTTMEN1KMT2ACYP1A2 | |
| SCHEMBL223728 | 0.80 | FFAR1 (0.44) | MEN1KMT2ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL3836804 | 0.80 | FFAR1 (0.40) | TP53HTTMEN1KMT2AFFAR1 | |
| SCHEMBL3834244 | 0.74 | MRGPRX4 (0.35) | MEN1KMT2AFFAR1L3MBTL1TDP1 | |
| SCHEMBL223566 | 0.73 | ALDH1A1 (0.50) | MEN1KMT2ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL224554 | 0.73 | LTA4H (0.50) | L3MBTL1TDP1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094668-A2 | 4-IMIDAZOLINES AS TAAR'S LIGANDS | F. Hoffmann-Roche AG (CH) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008074679-A2 | 4-IMIDAZOLINES AS TAAR'S LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-26 | — | — | WO | disclosed |