Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 4/20 | 0.44 |
| ▸ | CHUK | O15111 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4623114 | 0.91 | GPR119 (0.47) | CCNA2CDK2CCNA1CCNT1CDK9 | |
| SCHEMBL3836986 | 0.86 | GPR119 (0.49) | CCNA2CDK2CCNA1CCNT1CDK9 | |
| SCHEMBL3586147 | 0.84 | CCNA2 (0.47) | CCNA2CDK2CCNA1CCNT1CDK9 | |
| SCHEMBL8315814 | 0.79 | CDK2 (0.67) | CCNA2CDK2CCNA1CCNT1CDK9 | |
| SCHEMBL13054026 | 0.77 | GPR119 (0.58) | GPR119IKBKB | |
| SCHEMBL3752806 | 0.75 | PTPN2 (0.55) | JAK2JAK3IKBKBCHUK | |
| SCHEMBL4623116 | 0.74 | L3MBTL1 (0.46) | CCNA2CDK2CCNA1CCNT1CDK9 | |
| SCHEMBL5466244 | 0.74 | STS (0.49) | GPR119 | |
| SCHEMBL25068549 | 0.74 | CCNA2 (0.73) | CCNA2CDK2CCNA1CCNT1CDK9 | |
| SCHEMBL3595943 | 0.72 | IKBKB (0.61) | IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111395-A1 | NEW PHENYL- (4-PHENYL-PYRIMIDIN-2-YL) - AMINES DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF ESSENTIALLY AS IKK INHIBITORS | Sanofi-Aventis (FR) | 2009-10-28 | — | — | EP | disclosed |
| WO-2008099074-A1 | PHENYL- (4-PHENYL-PYRIMIDIN-2-YL) - AMINE DERIVATIVES AS IKK INHIBITORS, PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS THEREOF | SANOFI-AVENTIS (FR) | 2008-08-21 | — | — | WO | disclosed |