Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | HTR5A | P47898 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL590594 | 0.78 | MTNR1A (0.42) | PDE4APDE4CPDE4DMCHR1METAP2 | |
| SCHEMBL15237684 | 0.78 | MCHR1 (0.55) | PDE4APDE4CPDE4DMCHR1DRD2 | |
| SCHEMBL17430074 | 0.78 | MCHR1 (0.53) | PDE4APDE4CPDE4DMCHR1DRD2 | |
| SCHEMBL17430077 | 0.78 | PDE4A (0.41) | PDE4APDE4CPDE4DSLC40A1HSD11B1 | |
| SCHEMBL5764703 | 0.78 | BACE1 (0.42) | PDE4APDE4CPDE4DMCHR1SLC40A1 | |
| SCHEMBL7210273 | 0.76 | PDE4A (0.34) | PDE4APDE4CPDE4DHSD11B1MTNR1A | |
| SCHEMBL7590752 | 0.76 | MTNR1A (0.36) | PDE4APDE4CPDE4DHSD11B1MTNR1A | |
| SCHEMBL7210527 | 0.75 | ALDH1A1 (0.38) | PDE4APDE4CPDE4DMCHR1HSD11B1 | |
| SCHEMBL22573236 | 0.75 | PDE4A (0.46) | PDE4APDE4CPDE4DSLC40A1METAP2 | |
| SCHEMBL7254011 | 0.75 | MCHR1 (0.36) | MCHR1CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594858-B1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PROD INC (US) | 2009-10-14 | — | — | EP | disclosed |
| US-7071337-B2 | Benzoimidazole derivatives useful as antiproliferative agents | PFIZER INC (US) | 2006-07-04 | — | — | US | disclosed |
| US-7019147-B1 | Benzimidazole derivatives useful as antiproliferative agents | PFIZER INC. (US) | 2006-03-28 | — | — | US | disclosed |
| EP-1235825-B1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PROD INC (US) | 2006-01-25 | — | — | EP | disclosed |
| EP-1594858-A2 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | Pfizer Products Inc. (US) | 2005-11-16 | — | — | EP | disclosed |
| US-20050124599-A1 | Novel benzoimidazole derivatives useful as antiproliferative agents | PFIZER INC. | 2005-06-09 | — | — | US | disclosed |
| WO-2004020431-A2 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PRODUCTS INC. (US) | 2004-03-11 | — | — | WO | disclosed |
| EP-1235825-A1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | Pfizer Products Inc. (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001040217-A1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PRODUCTS INC. (US) | 2001-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124599-A1 | Novel benzoimidazole derivatives useful as antiproliferative agents | CCNI, CCNT1, CCNA1 | PDE4A 2208/4885PDE4C 3199/4885PDE4D 3205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.