Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3509664 | 0.94 | PTGER3 (0.32) | PTGER3GBA1 | |
| SCHEMBL62739 | 0.89 | GBA1 (0.37) | GBA1 | |
| SCHEMBL62176 | 0.89 | PTGER3 (0.31) | PTGER3ALDH1A1MAPTNUDT1 | |
| SCHEMBL63143 | 0.88 | PIK3CD (0.35) | PTGER3MEN1KMT2AALDH1A1NUDT1 | |
| SCHEMBL62172 | 0.87 | MEN1 (0.34) | MAPK1MEN1KMT2A | |
| SCHEMBL62683 | 0.87 | TSHR (0.36) | PTGER3MAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL62209 | 0.86 | GBA1 (0.31) | GBA1NUDT1 | |
| SCHEMBL61175 | 0.85 | CYP11B2 (0.41) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL61696 | 0.85 | PIK3CD (0.33) | PTGER3 | |
| SCHEMBL61296 | 0.77 | ELANE (0.33) | MAPK1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745033-A4 | 4,5-DISUBSTITUTED-2-ARYL PYRIMIDINES | NEUROGEN CORP (US) | 2009-08-26 | — | — | EP | claimed |
| EP-1745033-A2 | 4,5-DISUBSTITUTED-2-ARYL PYRIMIDINES | NEUROGEN CORPORATION (US) | 2007-01-24 | — | — | EP | claimed |
| WO-2005110416-A2 | 4,5-DISUBSTITUTED-2-ARYL PYRIMIDINES | NEUROGEN CORPORATION (US) | 2005-11-24 | — | — | WO | claimed |