Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.33 |
| ▸ | SMO | Q99835 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.31 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.31 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.30 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.30 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.30 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 2/20 | 0.30 |
| ▸ | HTR1D | P28221 | 2/20 | 0.30 |
| ▸ | HTR1B | P28222 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.30 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.30 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3509664 | 0.89 | PTGER3 (0.32) | PTGER3 | |
| SCHEMBL3837047 | 0.85 | PTGER3 (0.33) | PTGER3 | |
| SCHEMBL62176 | 0.82 | PTGER3 (0.31) | PTGER3 | |
| SCHEMBL62683 | 0.82 | TSHR (0.36) | KDM4EPTGER3 | |
| SCHEMBL61695 | 0.81 | PTGER3 (0.32) | PTGER3 | |
| SCHEMBL63143 | 0.81 | PIK3CD (0.35) | PIK3CDKDM4EHTR1AHTR1DHTR1B | |
| SCHEMBL61440 | 0.81 | OGA (0.33) | PIK3CD | |
| SCHEMBL62172 | 0.81 | MEN1 (0.34) | KDM4EHTR1ASLC6A4KCNH2 | |
| SCHEMBL62209 | 0.80 | GBA1 (0.31) | KDM4E | |
| SCHEMBL63402 | 0.80 | ADRA2A (0.34) | KDM4EHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129395-B2 | 4,5-disubstituted-2-aryl pyrimidines | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-03-06 | — | — | US | disclosed |