Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.44 |
| ▸ | MEN1 | O00255 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2952711 | 0.86 | MAPT (0.47) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL16474394 | 0.82 | MAPT (0.54) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL3833709 | 0.81 | MAPT (0.49) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL3837424 | 0.81 | MAPT (0.48) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL1265759 | 0.80 | MAPT (0.52) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL2960195 | 0.80 | ALDH1A1 (0.56) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL5650136 | 0.79 | MAPT (0.51) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL3836922 | 0.79 | CASP3 (0.47) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL2783455 | 0.78 | MAPT (0.50) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL3835945 | 0.77 | MAPT (0.49) | MAPTKMT2AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592455-B2 | Bicyclic heteroaromatic compounds as kinase inhibitors | UCB PHARMA S.A. (BE) | 2009-09-22 | — | — | US | claimed |
| US-20060025428-A1 | Bicyclic heteroaromatic compounds as kinase inhibitors | UCB PHARMA S.A. (BE) | 2006-02-02 | — | — | US | claimed |
| US-7592455-B2 | Bicyclic heteroaromatic compounds as kinase inhibitors | UCB PHARMA S.A. (BE) | 2009-09-22 | — | — | US | disclosed |
| US-20060025428-A1 | Bicyclic heteroaromatic compounds as kinase inhibitors | UCB PHARMA S.A. (BE) | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025428-A1 | Bicyclic heteroaromatic compounds as kinase inhibitors | MAP2K2, MAP2K7, MAP2K6 | MAPT 1954/4885KMT2A 2011/4885MEN1 4813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.