Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 2/20 | 0.35 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 11/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839958 | 0.92 | ATR (0.32) | ATRATRIPNR1H2IDO1TDO2 | |
| SCHEMBL3834957 | 0.83 | ATR (0.38) | ATRATRIPNR1H2IDO1TDO2 | |
| SCHEMBL3837061 | 0.82 | NTRK1 (0.36) | ATRATRIPNR1H2IDO1TDO2 | |
| SCHEMBL3835849 | 0.81 | NR1H2 (0.39) | ATRATRIPNR1H2 | |
| SCHEMBL3835602 | 0.79 | ALDH1A1 (0.38) | NR1H2 | |
| SCHEMBL3859943 | 0.79 | NR1H2 (0.35) | ATRATRIPNR1H2 | |
| SCHEMBL3863205 | 0.79 | HRH3 (0.39) | NR1H2 | |
| SCHEMBL5327142 | 0.78 | NR1H2 (0.51) | ATRATRIPNR1H2 | |
| SCHEMBL3835025 | 0.78 | PARP1 (0.40) | NR1H2 | |
| SCHEMBL3835632 | 0.78 | PARP1 (0.40) | NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |