Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 10/20 | 0.36 |
| ▸ | IDH2 | P48735 | 7/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3838179 | 0.77 | NT5E (0.30) | — | |
| SCHEMBL2526388 | 0.77 | TRPV1 (0.45) | NOTUMCYP3A4 | |
| SCHEMBL2533400 | 0.76 | KDM4E (0.44) | NOTUMCYP3A4 | |
| SCHEMBL2532480 | 0.75 | DPP4 (0.43) | P2RX7 | |
| SCHEMBL9952737 | 0.74 | LOXL2 (0.38) | NOTUMPDCD1LG2CD274P2RX7PNMT | |
| SCHEMBL2527872 | 0.72 | DPP4 (0.46) | — | |
| SCHEMBL2533480 | 0.72 | TRPV1 (0.43) | — | |
| SCHEMBL14798298 | 0.71 | TRPV1 (0.51) | — | |
| SCHEMBL119701 | 0.71 | CYP3A4 (0.64) | NOTUMIDH1IDH2CYP3A4TSHR | |
| SCHEMBL29447907 | 0.71 | CYP3A4 (0.64) | NOTUMIDH1IDH2CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086972-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008064255-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |