Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RORC | P51449 | 2/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 3/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3838426 | 0.77 | L3MBTL1 (0.58) | CA2L3MBTL1CNR2ALDH1A1LMNA | |
| SCHEMBL2103432 | 0.77 | SMN1; SMN2 (0.58) | CA2L3MBTL1CNR2ALDH1A1LMNA | |
| SCHEMBL3812813 | 0.75 | RORC (0.45) | CA2L3MBTL1ALDH1A1LMNARORC | |
| SCHEMBL13264275 | 0.75 | SMN1; SMN2 (0.34) | CA2ALDH1A1LMNARORC | |
| SCHEMBL7949428 | 0.75 | L3MBTL1 (0.57) | CA2L3MBTL1CNR2ALDH1A1LMNA | |
| SCHEMBL21033829 | 0.75 | L3MBTL1 (0.57) | CA2L3MBTL1CNR2ALDH1A1LMNA | |
| SCHEMBL27372293 | 0.75 | L3MBTL1 (0.57) | CA2L3MBTL1CNR2ALDH1A1LMNA | |
| SCHEMBL14253619 | 0.75 | L3MBTL1 (0.57) | CA2L3MBTL1CNR2ALDH1A1LMNA | |
| SCHEMBL15672905 | 0.75 | L3MBTL1 (0.57) | CA2L3MBTL1CNR2ALDH1A1LMNA | |
| SCHEMBL2103431 | 0.75 | L3MBTL1 (0.57) | CA2L3MBTL1CNR2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097385-A1 | 2-[1-PHENYL-5-HYDROXY OR METHOXY-4ALPHA-METHYL-HEXAHYDROCLOPENTA[F]INDAZOL-5-YL]ETHYL PHENYL DERIVATIVES AS GLUCOCORTICOID RECEPTOR LIGANDS | Merck & Co., Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008051532-A1 | 2-[1-PHENYL-5-HYDROXY OR METHOXY-4ALPHA-METHYL-HEXAHYDROCLOPENTA[F]INDAZOL-5-YL]ETHYL PHENYL DERIVATIVES AS GLUCOCORTICOID RECEPTOR LIGANDS | MERCK & CO., INC. (US) | 2008-05-02 | — | — | WO | disclosed |