Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1477661 | 0.84 | GRM5 (0.47) | GRM5MAPTALDH1A1LMNANPC1 | |
| SCHEMBL28723840 | 0.84 | GPR35 (0.47) | GRM5MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1028239 | 0.84 | MAPT (0.45) | GRM5MAPTALDH1A1FFAR1PTPN11 | |
| SCHEMBL1476179 | 0.82 | PDK1 (0.46) | GRM5PDGFRBKDR | |
| SCHEMBL3836707 | 0.81 | PTPN1 (0.57) | GRM5MAPTMEN1KMT2AHTT | |
| SCHEMBL4901069 | 0.79 | MAPT (0.68) | MAPTALDH1A1MEN1KMT2AHTT | |
| SCHEMBL1476533 | 0.79 | GRM5 (0.53) | GRM5 | |
| Fluoride SCHEMBL11786822 | 0.78 | MAPT (0.66) | MAPTALDH1A1MEN1KMT2AHTT | |
| SCHEMBL1477807 | 0.75 | GRM5 (0.56) | GRM5 | |
| SCHEMBL1477198 | 0.74 | MAPT (0.55) | GRM5MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729771-B1 | PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2009-10-14 | — | — | EP | disclosed |