SCHEMBL3838752

SCHEMBL3838752

Nc1nccnc1-c1nccs1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 10/20 0.53
ADORA1 P30542 10/20 0.47
ALDH1A1 P00352 1/20 0.46
TSHR P16473 1/20 0.46
NOS1 P29475 1/20 0.46
HSD17B10 Q99714 1/20 0.46
HSP90AA1 P07900 1/20 0.44
PDPK1 O15530 1/20 0.42
LOXL2 Q9Y4K0 1/20 0.41
CYP2A6 P11509 1/20 0.37
TGFBR1 P36897 1/20 0.37
ADORA3 P0DMS8 4/20 0.37
ADORA2B P29275 4/20 0.37
HDAC3 O15379 1/20 0.35
HDAC4 P56524 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC7 Q8WUI4 1/20 0.35
HDAC2 Q92769 1/20 0.35
HDAC10 Q969S8 1/20 0.35
HDAC11 Q96DB2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3663184 0.74 ADORA2A (0.47) ADORA2AADORA1ALDH1A1TSHRNOS1
SCHEMBL23224152 0.74 ADORA2A (0.41) ADORA2AADORA1ALDH1A1TSHRNOS1
SCHEMBL31631304 0.74 ADORA2A (0.47) ADORA2AADORA1ALDH1A1TSHRNOS1
SCHEMBL102331 0.72 PDPK1 (0.59) ADORA2AADORA1ALDH1A1TSHRNOS1
SCHEMBL28003149 0.71 CHEK2 (0.40) ADORA2AADORA1ALDH1A1TSHRNOS1
SCHEMBL29776129 0.71 ADORA2A (0.42) ADORA2AADORA1ALDH1A1TSHRNOS1
SCHEMBL23212719 0.71 ADORA2A (0.42) ADORA2AADORA1ALDH1A1TSHRNOS1
SCHEMBL30237754 0.71 ADORA2A (0.42) ADORA2AADORA1ALDH1A1TSHRNOS1
SCHEMBL30534095 0.70 PDPK1 (0.56) ADORA2AADORA1ALDH1A1TSHRNOS1
SCHEMBL30632310 0.70 PDPK1 (0.56) ADORA2AADORA1ALDH1A1TSHRNOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1501514-A4 PROTEIN KINASE MODULATORS AND METHODS OF USE EXELIXIS INC (US) 2009-08-26 EP claimed
EP-1501514-A2 PROTEIN KINASE MODULATORS AND METHODS OF USE Exelixis, Inc. (US) 2005-02-02 EP claimed
WO-2003093297-A2 PROTEIN KINASE MODULATORS AND METHODS OF USE EXELIXIS, INC. (US) 2003-11-13 WO claimed