Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29983575 | 0.75 | PARP1 (0.46) | CHEK2ECE1ADORA2AADORA1ALDH1A1 | |
| SCHEMBL2887102 | 0.75 | CHEK2 (0.43) | CHEK2ADORA2ALRRK2ADORA1PDPK1 | |
| SCHEMBL5597444 | 0.75 | PARP1 (0.46) | CHEK2ECE1ADORA2AADORA1ALDH1A1 | |
| SCHEMBL31238995 | 0.72 | ERCC1 (0.47) | CHEK2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL3838752 | 0.71 | ADORA2A (0.53) | CHEK2ADORA2AADORA1ALDH1A1PDPK1 | |
| SCHEMBL2492969 | 0.71 | TSHR (0.48) | ADORA2AADORA1ALDH1A1PDPK1TSHR | |
| SCHEMBL18113788 | 0.69 | CHEK2 (0.50) | CHEK2ECE1ADORA2AALDH1A1PDPK1 | |
| SCHEMBL6316389 | 0.69 | CHEK2 (0.39) | CHEK2ECE1ADORA2AADORA1ALDH1A1 | |
| SCHEMBL6649184 | 0.69 | ADORA2A (0.41) | CHEK2ECE1ADORA2ALRRK2ADORA1 | |
| SCHEMBL29290790 | 0.68 | ECE1 (0.46) | CHEK2ECE1ADORA2AADORA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104254534-B | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2017-07-14 | — | — | CN | disclosed |
| CN-104395752-A | Biomarkers for cancer responsive to modulators of HEC1 activity | TAIVEX THERAPEUTICS CORP | 2015-03-04 | — | — | CN | disclosed |