Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.70 |
| ▸ | GAK | O14976 | 2/20 | 0.70 |
| ▸ | ILK | Q13418 | 2/20 | 0.70 |
| ▸ | PLK4 | O00444 | 1/20 | 0.70 |
| ▸ | CIT | O14578 | 1/20 | 0.70 |
| ▸ | AURKA | O14965 | 1/20 | 0.70 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.70 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.70 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.70 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.70 |
| ▸ | BUB1 | O43683 | 1/20 | 0.70 |
| ▸ | KDM1A | O60341 | 1/20 | 0.70 |
| ▸ | JAK2 | O60674 | 1/20 | 0.70 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.70 |
| ▸ | STK17B | O94768 | 1/20 | 0.70 |
| ▸ | STK10 | O94804 | 1/20 | 0.70 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.70 |
| ▸ | ABL1 | P00519 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14490008 | 0.92 | FBP1 (0.69) | EGFRERBB2GAKILKPLK4 | |
| SCHEMBL29623516 | 0.92 | EGFR (0.68) | EGFRERBB2GAKILKPLK4 | |
| SCHEMBL209223 | 0.92 | EGFR (0.68) | EGFRERBB2GAKILKPLK4 | |
| SCHEMBL380507 | 0.89 | EGFR (0.66) | EGFRERBB2GAKILKPLK4 | |
| SCHEMBL14489923 | 0.88 | EGFR (0.70) | EGFRERBB2GAKILKPLK4 | |
| SCHEMBL12743352 | 0.88 | EGFR (0.73) | EGFRERBB2GAKILKPLK4 | |
| SCHEMBL12536534 | 0.87 | EGFR (0.68) | EGFRERBB2GAKILKPLK4 | |
| SCHEMBL14489921 | 0.86 | EGFR (0.67) | EGFRERBB2GAKILKPLK4 | |
| SCHEMBL14489979 | 0.86 | EGFR (0.77) | EGFRERBB2GAKILKPLK4 | |
| Erlotinib SCHEMBL33835 | 0.86 | EGFR (0.89) | EGFRERBB2GAKILKPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682147-B1 | USE OF TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY PROCESSES | BOEHRINGER INGELHEIM INT (DE) | 2009-10-07 | — | — | EP | claimed |