Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1266828 | 0.81 | HTR6 (0.38) | HTR6BRD4CCNE1CDK2 | |
| SCHEMBL3829505 | 0.77 | CYP2C9 (0.39) | HTR6BRD4CCNE1CDK2 | |
| SCHEMBL21294221 | 0.72 | BRD4 (0.39) | HTR6BRD4CCNE1CDK2 | |
| SCHEMBL3862087 | 0.71 | LCK (0.36) | HTR6BRD4CCNE1CDK2 | |
| SCHEMBL12675766 | 0.71 | HTR6 (0.39) | HTR6BRD4CCNE1CDK2 | |
| SCHEMBL3841208 | 0.70 | HTR6 (0.40) | HTR6BRD4CCNE1CDK2 | |
| SCHEMBL1268390 | 0.70 | CYP2C9 (0.41) | HTR6BRD4CCNE1CDK2 | |
| SCHEMBL1266811 | 0.70 | BRD4 (0.40) | HTR6BRD4CCNE1CDK2 | |
| SCHEMBL1267716 | 0.69 | HTR6 (0.51) | HTR6CCNE1CDK2 | |
| SCHEMBL28108723 | 0.69 | HTR6 (0.39) | HTR6BRD4CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086972-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008064255-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |