Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | GLS | O94925 | 2/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1118314 | 0.91 | KDM4E (0.44) | KDM4EMAPTTHRBGLSTRPV3 | |
| SCHEMBL1422597 | 0.86 | GPR119 (0.42) | KDM4EMAPTTHRBGLSTRPV3 | |
| SCHEMBL28310423 | 0.84 | ALDH1A1 (0.44) | KDM4EMAPTTHRBGPR119KMT2A | |
| SCHEMBL19839452 | 0.80 | GPR119 (0.62) | GPR119 | |
| SCHEMBL7920834 | 0.79 | PPARG (0.49) | MAPTGPR119KMT2AALDH1A1TSHR | |
| SCHEMBL1118608 | 0.79 | KDM4E (0.44) | KDM4EMAPTTHRBGLSGPR119 | |
| SCHEMBL1118433 | 0.79 | KDM4E (0.46) | KDM4EMAPTTHRBGLSTRPV3 | |
| SCHEMBL1118405 | 0.78 | MAPT (0.43) | KDM4EMAPTTHRBTRPV3GPR119 | |
| SCHEMBL30926307 | 0.78 | MEN1 (0.38) | KDM4EMAPTTHRBTRPV3GPR119 | |
| SCHEMBL23204035 | 0.77 | KDM4E (0.42) | KDM4EMAPTTHRBGLSGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3493807-A1 | OXYMETHYLENE ARYL COMPOUNDS FOR TREATING INFLAMMATORY GASTROINTESTINAL DISEASES OR GASTROINTESTINAL CONDITIONS | CymaBay Therapeutics, Inc. (US) | 2019-06-12 | — | — | EP | disclosed |
| WO-2018026890-A1 | OXYMETHYLENE ARYL COMPOUNDS FOR TREATING INFLAMMATORY GASTROINTESTINAL DISEASES OR GASTROINTESTINAL CONDITIONS | CYMABAY THERAPEUTICS (US) | 2018-02-08 | — | — | WO | disclosed |
| EP-2111107-A2 | HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS | Metabolex Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2008083238-A2 | HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS | METABOLEX INC. (US) | 2008-07-10 | — | — | WO | disclosed |