Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.38 |
| ▸ | HTR2A | P28223 | 5/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2796082 | 0.88 | KCNH2 (0.39) | KCNH2HTR2A | |
| SCHEMBL4775755 | 0.86 | KCNH2 (0.41) | KCNH2HTR2A | |
| SCHEMBL4778333 | 0.83 | KCNH2 (0.43) | KCNH2 | |
| SCHEMBL3840176 | 0.81 | KCNH2 (0.45) | KCNH2KCNQ1CACNA1C | |
| SCHEMBL4775988 | 0.81 | KCNH2 (0.51) | KCNH2 | |
| SCHEMBL2796259 | 0.80 | KCNH2 (0.39) | KCNH2KCNQ1CACNA1C | |
| SCHEMBL2796662 | 0.79 | KCNH2 (0.49) | KCNH2KCNQ1CACNA1C | |
| SCHEMBL2797333 | 0.79 | UBE2M (0.38) | KCNH2 | |
| SCHEMBL4303636 | 0.78 | KCNH2 (0.43) | KCNH2KCNQ1CACNA1C | |
| SCHEMBL4779477 | 0.77 | KCNH2 (0.57) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044077-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | Glaxo Group Limited (GB) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008009700-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |