Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | BLM | P54132 | 2/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4525215 | 0.84 | LMNA (0.59) | SLC6A1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL3842824 | 0.80 | SLC6A1 (0.57) | SLC6A1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL3862550 | 0.79 | SLC6A1 (0.53) | SLC6A1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL3841814 | 0.79 | SLC6A1 (0.56) | SLC6A1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL9562561 | 0.78 | SLC6A1 (0.51) | SLC6A1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL3843644 | 0.78 | SLC6A1 (0.55) | SLC6A1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL3837323 | 0.76 | SLC6A1 (0.53) | SLC6A1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL6551383 | 0.75 | SLC6A1 (0.52) | SLC6A1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL336164 | 0.72 | CHRM2 (0.65) | LMNABLMPMP22CYP1A2CYP2D6 | |
| SCHEMBL3837835 | 0.71 | HTR2C (0.41) | SLC6A1KMT2AKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931341-B1 | 1H-INDOLE-PYRIDINECARBOXAMIDE AND 1H-INDOLE-PIPERIDINECARBOXAMIDE DERIVATIVES AND THEIR USE AS TYROSINE HYDROXYLASE INDUCERS | SERVIER LAB (FR) | 2009-11-04 | — | — | EP | disclosed |