SCHEMBL3840338

SCHEMBL3840338

Clc1cccc(-c2cnc(OC3CN4CCC3CC4)nc2)c1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.49
RXFP1 Q9HBX9 1/20 0.49
CHRM2 P08172 2/20 0.48
CHRM1 P11229 2/20 0.48
CHRM3 P20309 2/20 0.48
MAPT P10636 1/20 0.48
CHRNA7 P36544 1/20 0.43
LSS P48449 1/20 0.43
MAPK1 P28482 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
CNR2 P34972 1/20 0.41
GLA P06280 1/20 0.40
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
CHRM4 P08173 1/20 0.38
CHRM5 P08912 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3840502 1.00 TSHR (0.49) TSHRRXFP1CHRM2CHRM1CHRM3
SCHEMBL16642070 0.91 TSHR (0.45) TSHRRXFP1CHRM2CHRM1CHRM3
SCHEMBL3839960 0.88 CHRNA7 (0.43) TSHRRXFP1CHRM2CHRM1CHRM3
SCHEMBL3844172 0.86 CHRNA7 (0.48) CHRM2CHRM1CHRM3CHRNA7
SCHEMBL3844170 0.86 CHRNA7 (0.48) CHRM2CHRM1CHRM3CHRNA7
SCHEMBL3844040 0.86 LSS (0.51) TSHRRXFP1CHRM2CHRM1CHRM3
SCHEMBL3843580 0.85 CHRNA7 (0.51) CHRM2CHRM1CHRM3CHRNA7
SCHEMBL3843584 0.85 CHRNA7 (0.51) CHRM2CHRM1CHRM3CHRNA7
SCHEMBL5397013 0.85 MAP4K4 (0.47) CHRM2CHRM1CHRM3CHRNA7CHRM4
SCHEMBL3839954 0.85 CHRM2 (0.47) TSHRRXFP1CHRM2CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9012451-B2 Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists NOVARTIS AG (CH) 2015-04-21 US claimed
EP-1537104-B1 AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS NOVARTIS AG (CH) 2009-11-11 EP claimed
US-9012451-B2 Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists NOVARTIS AG (CH) 2015-04-21 US disclosed
US-9012451-B2 Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists NOVARTIS AG (CH) 2015-04-21 US disclosed