Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PTPRB | P23467 | 1/20 | 0.35 |
| ▸ | PTPRG | P23470 | 1/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | PTPN3 | P26045 | 1/20 | 0.35 |
| ▸ | PTPRM | P28827 | 1/20 | 0.35 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | PTPN9 | P43378 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3376495 | 0.90 | GRM5 (0.43) | GRM5RAB9AFAAHNPC1MAOB | |
| SCHEMBL3835764 | 0.83 | GRM5 (0.46) | GRM5RAB9ANPC1PTPRCPTPN2 | |
| SCHEMBL3836423 | 0.80 | GRM5 (0.58) | GRM5RAB9ANPC1 | |
| SCHEMBL3837282 | 0.80 | GRM5 (0.58) | GRM5RAB9ANPC1 | |
| SCHEMBL3836422 | 0.80 | GRM5 (0.58) | GRM5RAB9ANPC1 | |
| SCHEMBL3841449 | 0.79 | GRM5 (0.46) | GRM5RAB9AFAAHPTPRCPTPN2 | |
| SCHEMBL3836682 | 0.79 | GRM5 (0.46) | GRM5RAB9ANPC1 | |
| SCHEMBL3841794 | 0.79 | GRM5 (0.46) | GRM5RAB9AFAAHPTPRCPTPN2 | |
| SCHEMBL3836458 | 0.77 | GRM5 (0.52) | GRM5MAOB | |
| SCHEMBL3860245 | 0.77 | GRM5 (0.52) | GRM5MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877367-B1 | ACETYLENE DERIVATIVES | NOVARTIS AG (CH) | 2009-10-14 | — | — | EP | claimed |