Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 4/20 | 0.37 |
| ▸ | THRB | P10828 | 4/20 | 0.37 |
| ▸ | RARB | P10826 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3843700 | 0.98 | SMPD1 (0.39) | SMPD1TP53TSHRPLA2G4BTHRA | |
| SCHEMBL3841422 | 0.92 | PKM (0.34) | TSHRHTTSMN1; SMN2LMNARAB9A | |
| SCHEMBL3841060 | 0.91 | PPARG (0.39) | SMPD1TP53TSHRPLA2G4BRARB | |
| SCHEMBL3842013 | 0.90 | PPARG (0.44) | SMPD1HTTSMN1; SMN2LMNARAB9A | |
| SCHEMBL3841221 | 0.90 | PPARA (0.41) | SMN1; SMN2S1PR1S1PR3PPARGPPARA | |
| SCHEMBL3848920 | 0.89 | PPARG (0.43) | SMPD1HTTSMN1; SMN2LMNARAB9A | |
| SCHEMBL3849934 | 0.88 | PPARG (0.38) | SMPD1TP53TSHRPLA2G4BRARB | |
| SCHEMBL3842276 | 0.87 | TP53 (0.39) | TP53TSHRPLA2G4BRARBHTT | |
| SCHEMBL3846393 | 0.85 | TP53 (0.39) | TP53TSHRPLA2G4BRARBHTT | |
| SCHEMBL3292828 | 0.84 | PPARA (0.40) | SMPD1TSHRHTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | claimed |