Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LSS | P48449 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840773 | 1.00 | CHRNA7 (0.53) | CHRNA7CYP1A2CYP2D6ALDH1A1LSS | |
| SCHEMBL1459282 | 0.87 | CHRNA7 (0.53) | CHRNA7CYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL1459280 | 0.87 | CHRNA7 (0.53) | CHRNA7CYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL3839223 | 0.84 | CHRNA7 (0.53) | CHRNA7CYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL3839228 | 0.84 | CHRNA7 (0.53) | CHRNA7CYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL3840517 | 0.84 | CHRNA7 (0.54) | CHRNA7LSSGLAGAAATM | |
| SCHEMBL3840519 | 0.84 | CHRNA7 (0.54) | CHRNA7LSSGLAGAAATM | |
| SCHEMBL3842064 | 0.81 | CHRNA7 (0.47) | CHRNA7CYP1A2CYP2D6 | |
| SCHEMBL3839401 | 0.81 | CHRNA7 (0.47) | CHRNA7CYP1A2CYP2D6 | |
| SCHEMBL3839400 | 0.81 | CHRNA7 (0.69) | CHRNA7CYP1A2CYP2D6LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236803-B2 | Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonists | NOVARTIS AG (CH) | 2012-08-07 | — | — | US | claimed |
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |