Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.32 |
| ▸ | F10 | P00742 | 2/20 | 0.32 |
| ▸ | CFD | P00746 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | FPR1 | P21462 | 1/20 | 0.30 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | NPY2R | P49146 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3841699 | 0.92 | KMT2A (0.33) | F10TP53ROCK2 | |
| SCHEMBL3833888 | 0.92 | KMT2A (0.33) | F10TP53ROCK2 | |
| SCHEMBL1639122 | 0.89 | KEAP1 (0.40) | KEAP1NFE2L2F10CFDCYP1A2 | |
| SCHEMBL3840521 | 0.84 | F10 (0.38) | F10 | |
| SCHEMBL3836155 | 0.84 | F10 (0.38) | F10 | |
| SCHEMBL3838472 | 0.83 | MAPT (0.33) | TP53 | |
| SCHEMBL1640224 | 0.80 | ROCK2 (0.43) | F10CYP1A2ROCK2 | |
| SCHEMBL1639571 | 0.80 | ROCK2 (0.43) | F10CYP1A2ROCK2 | |
| SCHEMBL3834322 | 0.79 | ADORA2A (0.37) | ROCK2 | |
| SCHEMBL3840059 | 0.79 | ADORA2A (0.37) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101534832-A | Substituted nitrogen containing heterocycles as platelet ADP receptor inhibitors | PORTOLA PHARM INC (US) | 2009-09-16 | — | — | CN | claimed |
| EP-2094272-A2 | NITROGEN CONTAINING SUBSTITUTED HETEROCYCLES AS PLATELET ADP RECEPTOR INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2009-09-02 | — | — | EP | claimed |
| WO-2008036843-A2 | NITROGEN CONTAINING SUBSTITUTED HETEROCYCLES AS PLATELET ADP RECEPTOR INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | claimed |
| CN-101534832-A | Substituted nitrogen containing heterocycles as platelet ADP receptor inhibitors | PORTOLA PHARM INC (US) | 2009-09-16 | — | — | CN | disclosed |