Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Chlortetracycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.71 |
| ▸ | MAPT | P10636 | 6/20 | 0.71 |
| ▸ | USP2 | O75604 | 5/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.71 |
| ▸ | GAA | P10253 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | THRB | P10828 | 2/20 | 0.70 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.70 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | PDE4A | P27815 | 1/20 | 0.70 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlortetracycline SCHEMBL29362279 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL3842 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL13782533 | 0.99 | MAPT (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL5503038 | 0.99 | MAPT (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL13782583 | 0.99 | MAPT (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL16726392 | 0.99 | MAPT (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL10901448 | 0.99 | MAPT (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL3110 | 0.99 | MAPT (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL20952683 | 0.99 | MAPT (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL12356689 | 0.99 | MAPT (0.71) | MEN1KMT2ATDP1MAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 11109 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122071006-A | Urea modified Bi2O3/g-C3N4Heterojunction catalyst and preparation method and application thereof | 武汉纺织大学 | 2026-05-22 | — | — | CN | claimed |
| US-20260139860-A1 | PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS | CENTRE FOR DIGESTIVE DISEASES (AU) | 2026-05-21 | — | — | US | claimed |
| CN-116083472-B | Recombinant vector, recombinant strain, kit, application of recombinant vector and recombinant strain and method for producing aureomycin | 金河生物科技股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122032649-A | MnO (MnO)2EDTA catalyst and its prepn and application | 昆明理工大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122004360-A | Natural plant feed raw material capable of replacing aureomycin and preparation method thereof | 山西朗新生物科技有限公司 | 2026-05-12 | — | — | CN | claimed |
| EP-4680248-A1 | PRODUCTS OF MANUFACTURE AND THERAPEUTIC COMPOSITIONS FOR TREATING, AMELIORATING OR PREVENTING VIRAL INFECTIONS AND METHODS FOR MAKING AND USING THEM | Topelia Aust Limited (ACN 652 771 670) (AU) | 2026-01-21 | — | — | EP | claimed |
| US-20250269005-A1 | METHODS FOR TREATING, AMELIORATING OR PREVENTING INFECTIONS USING DRUG AND VACCINATION COMBINATION TREATMENT | TOPELIA AUST LIMITED (ACN 652 771 670) (AU) | 2025-08-28 | — | — | US | claimed |
| CN-120136235-A | Treatment method and device for degrading tetracycline antibiotics in wastewater based on solar energy | 汕头大学 | 2025-06-13 | — | — | CN | claimed |
| CN-120142264-A | Ratio fluorescent probe for detecting aureomycin in meat food and detection method | 河北大学 | 2025-06-13 | — | — | CN | claimed |
| CN-115557975-B | Cu-based mixed ligand photo-Fenton catalyst and preparation method and application thereof | 辽宁大学 | 2025-06-13 | — | — | CN | claimed |
| EP-0259904-B1 | ADVANCED ANTICANCER THERAPY AND CYTOTOXIC MEDICAMENTS FOR ITS IMPLEMENTATION | IntraCel Corporation (BB) | 1991-06-12 | — | — | EP | claimed |
| EP-0372130-A1 | Coating medical devices with cationic antibiotics | C.R. BARD, INC. (US) | 1990-06-13 | — | — | EP | claimed |
| US-4736024-A | Process for preparing salt of hyaluronic acid with a pharmaceutically active substance | FIDIA, S.P.A. (IT) | 1988-04-05 | — | — | US | claimed |
| EP-0259904-A1 | Advanced anticancer therapy and cytotoxic medicaments for its implementation | IntraCel Corporation (BB) | 1988-03-16 | — | — | EP | claimed |
| EP-0201057-A2 | Bone targeted inhibitors of carbonic anhydrase | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1986-11-12 | — | — | EP | claimed |
| EP-0197718-A2 | New medicaments for topical use | FIDIA S.p.A. (IT) | 1986-10-15 | — | — | EP | claimed |
| US-4126680-A | TETRACYCLINE ANTIBIOTIC COMPOSITIONS | PFIZER INC. (US) | 1978-11-21 | — | — | US | claimed |
| US-4122158-A | FOR TREATMENT OF BURNS; BIODEGRADABLE HYDROPHOBIC POLYMER; SUSTAINED RELEASE | ALZA CORPORATION (US) | 1978-10-24 | — | — | US | claimed |
| US-4081527-A | Chlortetracycline compositions | PFIZER INC. (US) | 1978-03-28 | — | — | US | claimed |
| US-3983209-A | HYDROPHOBIC BIOERODIBLE POLYMER, MICROBIOCIDE OR PROTEOLYTIC ENZYME | ALZA CORPORATION (US) | 1976-09-28 | — | — | US | claimed |