Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Chlortetracycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.71 |
| ▸ | MAPT | P10636 | 6/20 | 0.71 |
| ▸ | USP2 | O75604 | 5/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.71 |
| ▸ | GAA | P10253 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | THRB | P10828 | 2/20 | 0.70 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.70 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | PDE4A | P27815 | 1/20 | 0.70 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlortetracycline SCHEMBL29362279 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL3841 | 1.00 | MEN1 (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL13782533 | 0.99 | MAPT (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL5503038 | 0.99 | MAPT (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL13782583 | 0.99 | MAPT (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL16726392 | 0.99 | MAPT (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL10901448 | 0.99 | MAPT (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL3110 | 0.99 | MAPT (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL20952683 | 0.99 | MAPT (0.71) | MEN1KMT2ATDP1MAPTUSP2 | |
| Chlortetracycline SCHEMBL12356689 | 0.99 | MAPT (0.71) | MEN1KMT2ATDP1MAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3358 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122071006-A | Urea modified Bi2O3/g-C3N4Heterojunction catalyst and preparation method and application thereof | 武汉纺织大学 | 2026-05-22 | — | — | CN | claimed |
| CN-120131995-A | Aureomycin hydrochloride clathrate, preparation method and application thereof, aureomycin hydrochloride injection and application thereof | 浦城正大生化有限公司 | 2025-06-13 | — | — | CN | claimed |
| WO-2025085377-A1 | USE OF ZOALENE IN LIVESTOCK | ZOETIS SERVICES LLC (US) | 2025-04-24 | — | — | WO | claimed |
| US-12274830-B2 | Nitric oxide inhalation therapy for infants with bronchiolitis | BEYOND AIR LTD (IL) | 2025-04-15 | — | — | US | claimed |
| CN-119657164-A | One-step in-situ preparation of compact-interface Z-type NiMn2O4Method for preparing NiO composite photocatalyst and application thereof | 辽宁大学 | 2025-03-21 | — | — | CN | claimed |
| CN-119346140-A | Bi plasma loaded Bi24O31Br10Nanosheet photocatalyst and preparation method and application thereof | 广东工业大学 | 2025-01-24 | — | — | CN | claimed |
| CN-119242301-A | Oil residue carbon dot, preparation method and application thereof in detection of mercury ions and aureomycin hydrochloride | 昆明市延安医院(昆明市干部疗养院) | 2025-01-03 | — | — | CN | claimed |
| CN-116120202-B | Crystallization preparation method of high-water-soluble aureomycin hydrochloride | 浦城正大生化有限公司 | 2024-12-24 | — | — | CN | claimed |
| CN-119000630-A | Quantitative detection method of aureomycin hydrochloride | 湖南科技大学 | 2024-11-22 | — | — | CN | claimed |
| CN-118988367-A | C with nitrogen defect and no metal flower cluster3N4Photocatalyst, preparation method and application thereof in degradation of tetracycline antibiotics | 浙江爱迪曼环保科技股份有限公司 | 2024-11-22 | — | — | CN | claimed |
| WO-1997006782-A1 | COMPOSITIONS INCLUDING O-CARBOXYALKYL CHITOSAN AND METHODS OF USE IN OPHTHALMICS | NOVARTIS AG (CH) | 1997-02-27 | — | — | WO | claimed |
| WO-1997000669-A1 | COMPOSITIONS AND METHODS FOR STABILIZING POLYMERS | NOVARTIS AG (CH) | 1997-01-09 | — | — | WO | claimed |
| EP-0741570-A1 | METHOD FOR PREVENTING OR REDUCING PHOTOSENSITIVITY AND/OR PHOTOTOXICITY REACTIONS TO MEDICATIONS | G.D. SEARLE & CO. (US) | 1996-11-13 | — | — | EP | claimed |
| WO-1995020387-A1 | METHOD FOR PREVENTING OR REDUCING PHOTOSENSITIVITY AND/OR PHOTOTOXICITY REACTIONS TO MEDICATIONS | G.D. SEARLE & CO. (US) | 1995-08-03 | — | — | WO | claimed |
| US-5357636-A | Flexible protective medical gloves and methods for their use | DRESDNER JR KARL P (US) | 1994-10-25 | — | — | US | claimed |
| EP-0201057-B1 | BONE TARGETED INHIBITORS OF CARBONIC ANHYDRASE | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1992-12-02 | — | — | EP | claimed |
| US-5167964-A | Coating of blend of ethyl acrylate-methacrylic acid copolymer and povidone | WARNER-LAMBERT COMPANY (US) | 1992-12-01 | — | — | US | claimed |
| EP-0201057-A2 | Bone targeted inhibitors of carbonic anhydrase | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1986-11-12 | — | — | EP | claimed |
| US-4126680-A | TETRACYCLINE ANTIBIOTIC COMPOSITIONS | PFIZER INC. (US) | 1978-11-21 | — | — | US | claimed |
| US-4081527-A | Chlortetracycline compositions | PFIZER INC. (US) | 1978-03-28 | — | — | US | claimed |